{"id":2620,"date":"2024-03-12T17:28:08","date_gmt":"2024-03-12T16:28:08","guid":{"rendered":"https:\/\/connected-pathology.com\/?p=2620"},"modified":"2024-03-12T17:40:28","modified_gmt":"2024-03-12T16:40:28","slug":"the-role-of-veterinary-dermatopathology-in-preclinical-research","status":"publish","type":"post","link":"https:\/\/connected-pathology.com\/?p=2620","title":{"rendered":"The Role of Veterinary Dermatopathology in Preclinical Research and Drug Development"},"content":{"rendered":"<p>[et_pb_section fb_built=&#8221;1&#8243; _builder_version=&#8221;4.20.2&#8243; _module_preset=&#8221;default&#8221; da_disable_devices=&#8221;off|off|off&#8221; global_colors_info=&#8221;{}&#8221; da_is_popup=&#8221;off&#8221; da_exit_intent=&#8221;off&#8221; da_has_close=&#8221;on&#8221; da_alt_close=&#8221;off&#8221; da_dark_close=&#8221;off&#8221; da_not_modal=&#8221;on&#8221; da_is_singular=&#8221;off&#8221; da_with_loader=&#8221;off&#8221; da_has_shadow=&#8221;on&#8221;][et_pb_row _builder_version=&#8221;4.20.2&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_column type=&#8221;4_4&#8243; _builder_version=&#8221;4.20.2&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_text _builder_version=&#8221;4.20.2&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<h2 style=\"text-align: justify;\"><span data-contrast=\"auto\" xml:lang=\"EN-GB\" lang=\"EN-GB\" class=\"TextRun MacChromeBold SCXW83005956 BCX0\"><span class=\"NormalTextRun SCXW83005956 BCX0\">What is veterinary dermatopathology?<\/span><\/span><span class=\"EOP SCXW83005956 BCX0\" data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335551550&quot;:6,&quot;335551620&quot;:6,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/h2>\n<p style=\"text-align: justify;\"><span data-contrast=\"auto\" xml:lang=\"EN-GB\" lang=\"EN-GB\" class=\"TextRun SCXW251814757 BCX0\"><span class=\"NormalTextRun SCXW251814757 BCX0\">Veterinary dermatopathology combines bridges the gap between two subspecialities in veterinary medicine, namely pathology and dermatology. <\/span><span class=\"NormalTextRun SCXW251814757 BCX0\">In the veterinary field, dermatopathology assessments play <\/span><span class=\"NormalTextRun SCXW251814757 BCX0\">an important role<\/span><span class=\"NormalTextRun SCXW251814757 BCX0\"> in diagnosing and <\/span><span class=\"NormalTextRun SCXW251814757 BCX0\">subsequently<\/span><span class=\"NormalTextRun SCXW251814757 BCX0\"> informing treatment outcomes of skin <\/span><span class=\"NormalTextRun SCXW251814757 BCX0\">lesions<\/span><span class=\"NormalTextRun SCXW251814757 BCX0\"> (<\/span><span class=\"NormalTextRun AdvancedProofingIssueV2Themed SCXW251814757 BCX0\">as a result of<\/span><span class=\"NormalTextRun SCXW251814757 BCX0\"> disease such as cancer, inflammatory <\/span><span class=\"NormalTextRun SCXW251814757 BCX0\">or autoimmune diseases affecting the skin<\/span><span class=\"NormalTextRun SCXW251814757 BCX0\">)<\/span><span class=\"NormalTextRun SCXW251814757 BCX0\"> <\/span><span class=\"NormalTextRun SCXW251814757 BCX0\">in a range of animals. However, veterinary dermatopathology has broader applications than just in veterinary <\/span><span class=\"NormalTextRun SCXW251814757 BCX0\">diagnostics and<\/span><span class=\"NormalTextRun SCXW251814757 BCX0\"> can be <\/span><span class=\"NormalTextRun SCXW251814757 BCX0\">further <\/span><span class=\"NormalTextRun SCXW251814757 BCX0\">applied to <\/span><span class=\"NormalTextRun SCXW251814757 BCX0\">the drug development field. <\/span><span class=\"NormalTextRun SCXW251814757 BCX0\">In this article, we outline the role that veterinary dermatopathology can play in preclinical research and drug development pipeline, with providing example histopathology cases.\u00a0<\/span><\/span><span class=\"EOP SCXW251814757 BCX0\" data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335551550&quot;:6,&quot;335551620&quot;:6,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/p>\n<h2 style=\"text-align: justify;\"><span class=\"EOP SCXW251814757 BCX0\" data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335551550&quot;:6,&quot;335551620&quot;:6,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\"><span data-contrast=\"auto\" xml:lang=\"EN-GB\" lang=\"EN-GB\" class=\"TextRun MacChromeBold SCXW255042734 BCX0\"><span class=\"NormalTextRun SCXW255042734 BCX0\">What role does veterinary dermatopathology play in the preclinical research field and drug development?\u00a0<\/span><\/span><\/span><\/h2>\n<p style=\"text-align: justify;\"><span data-contrast=\"auto\">Diseases affecting the skin affect almost one-third of human population, encompassing various skin malignancies (e.g. melanoma), inflammatory conditions (such as acne, rosacea, skin scleroderma\/ fibrosis, atopic dermatitis etc.,) and diseases with autoimmune origin (psoriasis, pemphigus etc.,). Given the high prevalence and burden of diseases affecting the skin, substantial research needs to be carried out to provide effective treatments. Before commencing clinical trials in human patients, efficacy of novel treatments to target skin-related diseases is evaluated, which is where veterinary dermatopathology plays a crucial role. <\/span><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335551550&quot;:6,&quot;335551620&quot;:6,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/p>\n<p style=\"text-align: justify;\"><span data-contrast=\"auto\">To test the efficacy of novel treatments to target skin-related diseases, preclinical animal models are needed for efficacy\/safety testing prior to conducting clinical trials. Therefore, veterinary dermatopathology assessments are crucial both when developing new animal models of skin diseases, but also when performing efficacy testing in already established rodent models of skin diseases.\u00a0<\/span><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335551550&quot;:6,&quot;335551620&quot;:6,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/p>\n<h3 style=\"text-align: justify;\"><span class=\"NormalTextRun SCXW57691302 BCX0\">What type of preclinical research studies may <\/span><span class=\"NormalTextRun SCXW57691302 BCX0\">benefit<\/span><span class=\"NormalTextRun SCXW57691302 BCX0\"> from veterinary dermatopathology assessments?<\/span><\/h3>\n<p style=\"text-align: justify;\"><span data-contrast=\"auto\">Preclinical research studies that evaluate the efficacy of novel compounds in a range of animal models of skin diseases need to undergo histopathology assessments performed by a certified veterinary pathologist. Example of studies include, but are not limited to:<\/span><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335551550&quot;:6,&quot;335551620&quot;:6,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/p>\n<ul style=\"text-align: justify;\">\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"4\" data-list-defn-props=\"{&quot;335552541&quot;:1,&quot;335559685&quot;:360,&quot;335559991&quot;:360,&quot;469769226&quot;:&quot;Symbol&quot;,&quot;469769242&quot;:[8226],&quot;469777803&quot;:&quot;left&quot;,&quot;469777804&quot;:&quot;\uf0b7&quot;,&quot;469777815&quot;:&quot;hybridMultilevel&quot;}\" aria-setsize=\"-1\" data-aria-posinset=\"1\" data-aria-level=\"1\"><span data-contrast=\"auto\">Efficacy studies of novel compounds performed in rodent models of wound healing, rosacea, psoriasis, skin scleroderma\/fibrosis, atopic dermatitis, acne\u00a0<\/span><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335551550&quot;:6,&quot;335551620&quot;:6,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/li>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"4\" data-list-defn-props=\"{&quot;335552541&quot;:1,&quot;335559685&quot;:360,&quot;335559991&quot;:360,&quot;469769226&quot;:&quot;Symbol&quot;,&quot;469769242&quot;:[8226],&quot;469777803&quot;:&quot;left&quot;,&quot;469777804&quot;:&quot;\uf0b7&quot;,&quot;469777815&quot;:&quot;hybridMultilevel&quot;}\" aria-setsize=\"-1\" data-aria-posinset=\"2\" data-aria-level=\"1\"><span data-contrast=\"auto\">Dermatological safety evaluation of test items \u00a0in wild-type mice<\/span><\/li>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"4\" data-list-defn-props=\"{&quot;335552541&quot;:1,&quot;335559685&quot;:360,&quot;335559991&quot;:360,&quot;469769226&quot;:&quot;Symbol&quot;,&quot;469769242&quot;:[8226],&quot;469777803&quot;:&quot;left&quot;,&quot;469777804&quot;:&quot;\uf0b7&quot;,&quot;469777815&quot;:&quot;hybridMultilevel&quot;}\" aria-setsize=\"-1\" data-aria-posinset=\"3\" data-aria-level=\"1\"><span data-contrast=\"auto\">Pathological evaluation of topical drugs and medical devices in the (SKH1) hairless mouse model<\/span><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335551550&quot;:6,&quot;335551620&quot;:6,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/li>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"4\" data-list-defn-props=\"{&quot;335552541&quot;:1,&quot;335559685&quot;:360,&quot;335559991&quot;:360,&quot;469769226&quot;:&quot;Symbol&quot;,&quot;469769242&quot;:[8226],&quot;469777803&quot;:&quot;left&quot;,&quot;469777804&quot;:&quot;\uf0b7&quot;,&quot;469777815&quot;:&quot;hybridMultilevel&quot;}\" aria-setsize=\"-1\" data-aria-posinset=\"4\" data-aria-level=\"1\"><span data-contrast=\"auto\">Evaluation and establishment of novel skin disease preclinical animal models\u00a0<\/span><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335551550&quot;:6,&quot;335551620&quot;:6,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/li>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"4\" data-list-defn-props=\"{&quot;335552541&quot;:1,&quot;335559685&quot;:360,&quot;335559991&quot;:360,&quot;469769226&quot;:&quot;Symbol&quot;,&quot;469769242&quot;:[8226],&quot;469777803&quot;:&quot;left&quot;,&quot;469777804&quot;:&quot;\uf0b7&quot;,&quot;469777815&quot;:&quot;hybridMultilevel&quot;}\" aria-setsize=\"-1\" data-aria-posinset=\"5\" data-aria-level=\"1\"><span data-contrast=\"auto\">Evaluation of topical compound\u2019s efficacy <\/span><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335551550&quot;:6,&quot;335551620&quot;:6,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/li>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"4\" data-list-defn-props=\"{&quot;335552541&quot;:1,&quot;335559685&quot;:360,&quot;335559991&quot;:360,&quot;469769226&quot;:&quot;Symbol&quot;,&quot;469769242&quot;:[8226],&quot;469777803&quot;:&quot;left&quot;,&quot;469777804&quot;:&quot;\uf0b7&quot;,&quot;469777815&quot;:&quot;hybridMultilevel&quot;}\" aria-setsize=\"-1\" data-aria-posinset=\"6\" data-aria-level=\"1\"><span data-contrast=\"auto\">Evaluation of cosmetic products\u00a0<\/span><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335551550&quot;:6,&quot;335551620&quot;:6,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/li>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"4\" data-list-defn-props=\"{&quot;335552541&quot;:1,&quot;335559685&quot;:360,&quot;335559991&quot;:360,&quot;469769226&quot;:&quot;Symbol&quot;,&quot;469769242&quot;:[8226],&quot;469777803&quot;:&quot;left&quot;,&quot;469777804&quot;:&quot;\uf0b7&quot;,&quot;469777815&quot;:&quot;hybridMultilevel&quot;}\" aria-setsize=\"-1\" data-aria-posinset=\"7\" data-aria-level=\"1\"><span data-contrast=\"auto\">Biocompatibility assessment of the medical devices implanted subcutaneously\u00a0<\/span><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335551550&quot;:6,&quot;335551620&quot;:6,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/li>\n<\/ul>\n<h3 style=\"text-align: justify;\"><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335551550&quot;:6,&quot;335551620&quot;:6,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\"><span class=\"NormalTextRun SCXW201529216 BCX0\">What information can be obtained following <\/span><span class=\"NormalTextRun SCXW201529216 BCX0\">skin pathology assessment?<\/span><\/span><\/h3>\n<p style=\"text-align: justify;\"><span data-contrast=\"auto\">Depending on the skin pathology as well as the mechanism of action of the test compound, multiple histopathological outcomes are evaluated by the veterinary pathologist. Examples of histopathology lesions that can be identified include, but are not limited to:\u00a0<\/span><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335551550&quot;:6,&quot;335551620&quot;:6,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/p>\n<ul style=\"text-align: justify;\">\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"5\" data-list-defn-props=\"{&quot;335552541&quot;:1,&quot;335559685&quot;:360,&quot;335559991&quot;:360,&quot;469769226&quot;:&quot;Symbol&quot;,&quot;469769242&quot;:[8226],&quot;469777803&quot;:&quot;left&quot;,&quot;469777804&quot;:&quot;\uf0b7&quot;,&quot;469777815&quot;:&quot;hybridMultilevel&quot;}\" aria-setsize=\"-1\" data-aria-posinset=\"8\" data-aria-level=\"1\"><span data-contrast=\"auto\">Evaluation of inflammation; type of inflammatory infiltrates, their distribution and severity etc,.<\/span><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335551550&quot;:6,&quot;335551620&quot;:6,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/li>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"5\" data-list-defn-props=\"{&quot;335552541&quot;:1,&quot;335559685&quot;:360,&quot;335559991&quot;:360,&quot;469769226&quot;:&quot;Symbol&quot;,&quot;469769242&quot;:[8226],&quot;469777803&quot;:&quot;left&quot;,&quot;469777804&quot;:&quot;\uf0b7&quot;,&quot;469777815&quot;:&quot;hybridMultilevel&quot;}\" aria-setsize=\"-1\" data-aria-posinset=\"9\" data-aria-level=\"1\"><span data-contrast=\"auto\">Epidermal changes (inflammation, acanthosis, spongiosis, acantholysis etc.,)<\/span><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335551550&quot;:6,&quot;335551620&quot;:6,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/li>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"5\" data-list-defn-props=\"{&quot;335552541&quot;:1,&quot;335559685&quot;:360,&quot;335559991&quot;:360,&quot;469769226&quot;:&quot;Symbol&quot;,&quot;469769242&quot;:[8226],&quot;469777803&quot;:&quot;left&quot;,&quot;469777804&quot;:&quot;\uf0b7&quot;,&quot;469777815&quot;:&quot;hybridMultilevel&quot;}\" aria-setsize=\"-1\" data-aria-posinset=\"1\" data-aria-level=\"1\"><span data-contrast=\"auto\">Dermal changes such as fibrosis, inflammation, etc.,<\/span><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335551550&quot;:6,&quot;335551620&quot;:6,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/li>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"5\" data-list-defn-props=\"{&quot;335552541&quot;:1,&quot;335559685&quot;:360,&quot;335559991&quot;:360,&quot;469769226&quot;:&quot;Symbol&quot;,&quot;469769242&quot;:[8226],&quot;469777803&quot;:&quot;left&quot;,&quot;469777804&quot;:&quot;\uf0b7&quot;,&quot;469777815&quot;:&quot;hybridMultilevel&quot;}\" aria-setsize=\"-1\" data-aria-posinset=\"2\" data-aria-level=\"1\"><span data-contrast=\"auto\">Skin adnexa (hair follicles, sebaceous glands, sweet glands) histologic evaluation\u00a0<\/span><\/li>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"5\" data-list-defn-props=\"{&quot;335552541&quot;:1,&quot;335559685&quot;:360,&quot;335559991&quot;:360,&quot;469769226&quot;:&quot;Symbol&quot;,&quot;469769242&quot;:[8226],&quot;469777803&quot;:&quot;left&quot;,&quot;469777804&quot;:&quot;\uf0b7&quot;,&quot;469777815&quot;:&quot;hybridMultilevel&quot;}\" aria-setsize=\"-1\" data-aria-posinset=\"3\" data-aria-level=\"1\"><span data-contrast=\"auto\">Degenerative, necrotic and apoptotic changes<\/span><\/li>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"5\" data-list-defn-props=\"{&quot;335552541&quot;:1,&quot;335559685&quot;:360,&quot;335559991&quot;:360,&quot;469769226&quot;:&quot;Symbol&quot;,&quot;469769242&quot;:[8226],&quot;469777803&quot;:&quot;left&quot;,&quot;469777804&quot;:&quot;\uf0b7&quot;,&quot;469777815&quot;:&quot;hybridMultilevel&quot;}\" aria-setsize=\"-1\" data-aria-posinset=\"4\" data-aria-level=\"1\"><span data-contrast=\"auto\">Assessment of healing and repair; epithelialization, inflammation, angiogenesis etc.,\u00a0<\/span><\/li>\n<\/ul>\n<p style=\"text-align: justify;\"><span data-contrast=\"auto\">In the section below, we highlight multiple case studies of preclinical studies that were performed by expert laboratory technicians and evaluated by veterinary pathologist at Connected-Pathology.\u00a0<\/span><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335551550&quot;:6,&quot;335551620&quot;:6,&quot;335559685&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/p>\n<p style=\"text-align: justify;\"><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335551550&quot;:6,&quot;335551620&quot;:6,&quot;335559685&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\"><\/span><\/p>\n<h4 style=\"text-align: justify;\"><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335551550&quot;:6,&quot;335551620&quot;:6,&quot;335559685&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\"><span class=\"NormalTextRun SCXW73189595 BCX0\">Example s<\/span><span class=\"NormalTextRun SCXW73189595 BCX0\">kin lesions \u2013 <\/span><span class=\"NormalTextRun SCXW73189595 BCX0\">Preclinical Mouse model of <\/span><span class=\"NormalTextRun SCXW73189595 BCX0\">psoriasis <\/span><span class=\"NormalTextRun SCXW73189595 BCX0\">(IL-23 induced model of psoriasis)\u00a0<\/span><\/span><\/h4>\n<p><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335551550&quot;:6,&quot;335551620&quot;:6,&quot;335559685&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\"><span class=\"NormalTextRun SCXW73189595 BCX0\"><span data-contrast=\"auto\" xml:lang=\"EN-GB\" lang=\"EN-GB\" class=\"TextRun SCXW43632556 BCX0\"><span class=\"NormalTextRun SCXW43632556 BCX0\">H&amp;E-stained sections of ear skin confirm psoriasis-like lesions in the IL-23 induced model. <\/span><\/span><strong><span data-contrast=\"auto\" xml:lang=\"EN-GB\" lang=\"EN-GB\" class=\"TextRun MacChromeBold SCXW43632556 BCX0\"><span class=\"NormalTextRun SCXW43632556 BCX0\">(A)<\/span><\/span><\/strong><span data-contrast=\"auto\" xml:lang=\"EN-GB\" lang=\"EN-GB\" class=\"TextRun SCXW43632556 BCX0\"><span class=\"NormalTextRun SCXW43632556 BCX0\"> <\/span><span class=\"NormalTextRun SCXW43632556 BCX0\">S<\/span><span class=\"NormalTextRun SCXW43632556 BCX0\">pongiosis<\/span><span class=\"NormalTextRun SCXW43632556 BCX0\"> in the epidermis<\/span><span class=\"NormalTextRun SCXW43632556 BCX0\">. <\/span><\/span><span data-contrast=\"auto\" xml:lang=\"EN-GB\" lang=\"EN-GB\" class=\"TextRun MacChromeBold SCXW43632556 BCX0\"><span class=\"NormalTextRun SCXW43632556 BCX0\"><strong>(B)<\/strong> <\/span><\/span><span data-contrast=\"auto\" xml:lang=\"EN-GB\" lang=\"EN-GB\" class=\"TextRun SCXW43632556 BCX0\"><span class=\"NormalTextRun SCXW43632556 BCX0\">M<\/span><span class=\"NormalTextRun SCXW43632556 BCX0\">unro\u2019s abscess in the surface of epidermis<\/span><span class=\"NormalTextRun SCXW43632556 BCX0\">, which is diagnostic <\/span><span class=\"NormalTextRun SCXW43632556 BCX0\">criteria<\/span><span class=\"NormalTextRun SCXW43632556 BCX0\"> for <\/span><span class=\"NormalTextRun SCXW43632556 BCX0\">psoriasis<\/span><span class=\"NormalTextRun SCXW43632556 BCX0\">.<\/span><span class=\"NormalTextRun SCXW43632556 BCX0\">\u00a0<\/span><\/span><\/span><\/span><\/p>\n<p><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335551550&quot;:6,&quot;335551620&quot;:6,&quot;335559685&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\"><span class=\"NormalTextRun SCXW73189595 BCX0\"><span class=\"EOP SCXW43632556 BCX0\" data-ccp-props=\"{&quot;134233117&quot;:false,&quot;134233118&quot;:false,&quot;201341983&quot;:0,&quot;335551550&quot;:6,&quot;335551620&quot;:6,&quot;335559685&quot;:0,&quot;335559737&quot;:0,&quot;335559738&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\"><\/span><\/span><\/span><\/p>\n<p>[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=&#8221;4.20.2&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_column type=&#8221;4_4&#8243; _builder_version=&#8221;4.20.2&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_image src=&#8221;https:\/\/connected-pathology.com\/wp-content\/uploads\/2024\/03\/Screenshot-2024-03-12-at-17.14.39.png&#8221; title_text=&#8221;Screenshot 2024-03-12 at 17.14.39&#8243; _builder_version=&#8221;4.20.2&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][\/et_pb_image][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=&#8221;4.20.2&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_column type=&#8221;4_4&#8243; _builder_version=&#8221;4.20.2&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_text _builder_version=&#8221;4.20.2&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<h4 style=\"text-align: justify;\"><span class=\"NormalTextRun SCXW96895083 BCX0\">Example s<\/span><span class=\"NormalTextRun SCXW96895083 BCX0\">kin lesions<\/span><span class=\"NormalTextRun SCXW96895083 BCX0\"> \u2013 Preclinical mouse model of skin <\/span><span class=\"NormalTextRun SCXW96895083 BCX0\">inflammation\u00a0<\/span><\/h4>\n<p style=\"text-align: justify;\"><span data-contrast=\"auto\">The H&amp;E-stained digitalized whole-slide images below show <\/span><b><span data-contrast=\"auto\">(A)<\/span><\/b><span data-contrast=\"auto\"> infiltration of immune cells consisting of mainly lymphocyte in the dermis around and inside a hair follicle (peri-folliculitis) <\/span><b><span data-contrast=\"auto\">(B)<\/span><\/b><span data-contrast=\"auto\"> Non-inflamed dermis in the control group.\u00a0<\/span><\/p>\n<p>[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=&#8221;4.20.2&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_column type=&#8221;4_4&#8243; _builder_version=&#8221;4.20.2&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_image src=&#8221;https:\/\/connected-pathology.com\/wp-content\/uploads\/2024\/03\/Screenshot-2024-02-26-at-14.47.04.png&#8221; title_text=&#8221;Screenshot 2024-02-26 at 14.47.04&#8243; _builder_version=&#8221;4.20.2&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][\/et_pb_image][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=&#8221;4.20.2&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_column type=&#8221;4_4&#8243; _builder_version=&#8221;4.20.2&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_text _builder_version=&#8221;4.20.2&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<h2 style=\"text-align: justify;\"><b><span data-contrast=\"auto\">What is the advantage in outsourcing your veterinary dermatopathology assessments?\u00a0<\/span><\/b><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/h2>\n<p style=\"text-align: justify;\"><span data-contrast=\"auto\">Outsourcing veterinary dermatopathology assessments to contract research organisations (CROs) can be advantageous for multiple reasons, which we outline below:<\/span><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335551550&quot;:6,&quot;335551620&quot;:6,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/p>\n<ul style=\"text-align: justify;\">\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"6\" data-list-defn-props=\"{&quot;335552541&quot;:1,&quot;335559685&quot;:360,&quot;335559991&quot;:360,&quot;469769226&quot;:&quot;Symbol&quot;,&quot;469769242&quot;:[8226],&quot;469777803&quot;:&quot;left&quot;,&quot;469777804&quot;:&quot;\uf0b7&quot;,&quot;469777815&quot;:&quot;hybridMultilevel&quot;}\" aria-setsize=\"-1\" data-aria-posinset=\"1\" data-aria-level=\"1\"><b><span data-contrast=\"auto\">Preclinical veterinary pathology expertise:<\/span><\/b><span data-contrast=\"auto\"> histopathology CROs process and assess hundreds of samples daily. Given the importance of knowing animal models\u2019 specific skin histologic features, by working with expert CROs you can get access to specialised knowledge, working with veterinary pathologists who are specialised in the field of veterinary dermatopathology.\u00a0<\/span><span data-ccp-props=\"{&quot;134233117&quot;:false,&quot;134233118&quot;:false,&quot;201341983&quot;:0,&quot;335551550&quot;:1,&quot;335551620&quot;:1,&quot;335559685&quot;:360,&quot;335559737&quot;:0,&quot;335559738&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:259,&quot;335559991&quot;:360}\">\u00a0<\/span><\/li>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"6\" data-list-defn-props=\"{&quot;335552541&quot;:1,&quot;335559685&quot;:360,&quot;335559991&quot;:360,&quot;469769226&quot;:&quot;Symbol&quot;,&quot;469769242&quot;:[8226],&quot;469777803&quot;:&quot;left&quot;,&quot;469777804&quot;:&quot;\uf0b7&quot;,&quot;469777815&quot;:&quot;hybridMultilevel&quot;}\" aria-setsize=\"-1\" data-aria-posinset=\"2\" data-aria-level=\"1\"><b><span data-contrast=\"none\">High-volume sample processing capabilities and technical processing: <\/span><\/b><span data-contrast=\"none\">Histopathology service providers have access and necessary capabilities to run high-volume studies thanks to automated sample processing and staining capabilities using state-of-the-art machinery.<\/span><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/li>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"6\" data-list-defn-props=\"{&quot;335552541&quot;:1,&quot;335559685&quot;:360,&quot;335559991&quot;:360,&quot;469769226&quot;:&quot;Symbol&quot;,&quot;469769242&quot;:[8226],&quot;469777803&quot;:&quot;left&quot;,&quot;469777804&quot;:&quot;\uf0b7&quot;,&quot;469777815&quot;:&quot;hybridMultilevel&quot;}\" aria-setsize=\"-1\" data-aria-posinset=\"3\" data-aria-level=\"1\"><b><span data-contrast=\"none\">Advice on future projects: <\/span><\/b><span data-contrast=\"none\">collaboration with histopathology CROs allows you to discuss your results with experts and obtain advice on future projects or can inform the next steps of the project.<\/span><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/li>\n<\/ul>\n<p style=\"text-align: justify;\"><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335559685&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/p>\n<h2 style=\"text-align: justify;\"><b><span data-contrast=\"auto\">Outsourcing your veterinary dermatopathology assessments with Connected-Pathology <\/span><\/b><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/h2>\n<p style=\"text-align: justify;\"><span data-contrast=\"auto\">By working with Connected-Pathology&#8217;s expert team, you can:\u00a0<\/span><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/p>\n<ul style=\"text-align: justify;\">\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"3\" data-list-defn-props=\"{&quot;335552541&quot;:1,&quot;335559685&quot;:360,&quot;335559991&quot;:360,&quot;469769226&quot;:&quot;Symbol&quot;,&quot;469769242&quot;:[8226],&quot;469777803&quot;:&quot;left&quot;,&quot;469777804&quot;:&quot;\uf0b7&quot;,&quot;469777815&quot;:&quot;hybridMultilevel&quot;}\" aria-setsize=\"-1\" data-aria-posinset=\"4\" data-aria-level=\"1\"><b><span data-contrast=\"auto\">Perform large-scale studies thanks to automated H&amp;E and IHC staining capacity: <\/span><\/b><span data-contrast=\"auto\">Fully automatised and digitalized laboratory workflows thanks to automated H&amp;E Dako stainer and Roche\u2019s BenchMark ULTRA IHC\/ISH and DISCOVERY ULTRA systems enable us to perform your large-scale studies with shorter turn-around times, whilst maintaining high quality of staining.<\/span><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/li>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"3\" data-list-defn-props=\"{&quot;335552541&quot;:1,&quot;335559685&quot;:360,&quot;335559991&quot;:360,&quot;469769226&quot;:&quot;Symbol&quot;,&quot;469769242&quot;:[8226],&quot;469777803&quot;:&quot;left&quot;,&quot;469777804&quot;:&quot;\uf0b7&quot;,&quot;469777815&quot;:&quot;hybridMultilevel&quot;}\" aria-setsize=\"-1\" data-aria-posinset=\"5\" data-aria-level=\"1\"><b><span data-contrast=\"auto\">Gain access to reliable and secure sample management system with our fully digital workflows:<\/span><\/b><span data-contrast=\"auto\"> Once your samples arrive at our laboratory, they receive a barcode ensuring full traceability alongside stringent quality control checks throughout the entirety of your study. To ensure further confidence in your study, simply view the processing status of your samples anytime from the comfort of your own browser thanks to our in-house cloud-based LIS, Tx-Connect.\u00a0\u00a0<\/span><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/li>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"3\" data-list-defn-props=\"{&quot;335552541&quot;:1,&quot;335559685&quot;:360,&quot;335559991&quot;:360,&quot;469769226&quot;:&quot;Symbol&quot;,&quot;469769242&quot;:[8226],&quot;469777803&quot;:&quot;left&quot;,&quot;469777804&quot;:&quot;\uf0b7&quot;,&quot;469777815&quot;:&quot;hybridMultilevel&quot;}\" aria-setsize=\"-1\" data-aria-posinset=\"6\" data-aria-level=\"1\"><b><span data-contrast=\"auto\">Gain full access to your whole slide digital images: <\/span><\/b><span data-contrast=\"auto\">Conveniently view and access all whole slide images of your study as soon as they are scanned via our I-Connect platform. Archive and store your results offline by simply downloading your images at 10K resolution in a PNG format or alternatively in the VSI format to view in your own software of choice.\u00a0\u00a0<\/span><b><span data-contrast=\"auto\">\u00a0<\/span><\/b><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/li>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"3\" data-list-defn-props=\"{&quot;335552541&quot;:1,&quot;335559685&quot;:360,&quot;335559991&quot;:360,&quot;469769226&quot;:&quot;Symbol&quot;,&quot;469769242&quot;:[8226],&quot;469777803&quot;:&quot;left&quot;,&quot;469777804&quot;:&quot;\uf0b7&quot;,&quot;469777815&quot;:&quot;hybridMultilevel&quot;}\" aria-setsize=\"-1\" data-aria-posinset=\"7\" data-aria-level=\"1\"><b><span data-contrast=\"auto\">Consult the next steps of your research with our experts<\/span><\/b><span data-contrast=\"auto\">: In-house expert veterinary and medical pathologists will help you from the very first steps of your research until reporting and assist you in deciding on the next steps of your investigation and compound development.\u00a0\u00a0<\/span><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/li>\n<\/ul>\n<p style=\"text-align: justify;\"><span class=\"NormalTextRun SCXW96895083 BCX0\"><\/span><\/p>\n<p>[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=&#8221;4.20.2&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_column type=&#8221;4_4&#8243; _builder_version=&#8221;4.20.2&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_button button_url=&#8221;https:\/\/connected-pathology.com\/contact\/&#8221; button_text=&#8221;Contact Us&#8221; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; custom_margin=&#8221;-25px|||||&#8221; locked=&#8221;off&#8221; global_colors_info=&#8221;{}&#8221;][\/et_pb_button][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/p>\n","protected":false},"excerpt":{"rendered":"<p>What is veterinary dermatopathology?\u00a0 Veterinary dermatopathology combines bridges the gap between two subspecialities in veterinary medicine, namely pathology and dermatology. In the veterinary field, dermatopathology assessments play an important role in diagnosing and subsequently informing treatment outcomes of skin lesions (as a result of disease such as cancer, inflammatory or autoimmune diseases affecting the skin) [&hellip;]<\/p>\n","protected":false},"author":7,"featured_media":2631,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","_monsterinsights_skip_tracking":false,"footnotes":""},"categories":[4],"tags":[],"class_list":["post-2620","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-services"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.5 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Preclinical Veterinary Dermatopathology - Connected-Pathology<\/title>\n<meta name=\"description\" content=\"Here we outline the role of veterinary dermatopathology in preclinical research and drug development pipelines.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/connected-pathology.com\/?p=2620\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Preclinical Veterinary Dermatopathology - 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