{"id":2707,"date":"2026-02-17T15:24:02","date_gmt":"2026-02-17T14:24:02","guid":{"rendered":"https:\/\/connected-pathology.com\/?p=2707"},"modified":"2026-02-17T15:35:52","modified_gmt":"2026-02-17T14:35:52","slug":"new-stain-for-lawsonia-intracellularis","status":"publish","type":"post","link":"https:\/\/connected-pathology.com\/?p=2707","title":{"rendered":"New stain for Lawsonia intracellularis"},"content":{"rendered":"\n<h2 class=\"wp-block-heading\">C-path successfully validated Warthin-Starry stain (WS)<\/h2>\n\n\n\n<p>Which is&nbsp;a silver-based histological special stain used to visualize&nbsp;<em>Lawsonia intracellularis <\/em>(<em>L. intracellularis<\/em>) and other microorganisms such as <em>Spirochetes<\/em> sp., <em>Brachyspira <\/em>sp., <em>Helicobacter<\/em> sp. and other argyrophilic (silver-stained) bacteria in histologic sections. WS is of particular importance to visualise <em>L. intracellularis <\/em>and correlate their presence to the hyperplastic lesions in swine intestines as this bacteria can not be detected with routine Hematoxylin and Eosin (HE) histologic stain. WS stain provides same level of specificity and sensitivity for detecting <em>L. intracellularis <\/em>as immunohistochemistry (IHC) does, however, WS is significantly cheaper and less technically challenging than IHC.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><br>C-path is currently developing<\/h2>\n\n\n\n<p>Other special stains for microorganisms such as Gram stain that visualise gram-positive and gram-negative bacteria. In addition, we are also planning to introduce IHC toolbox for important viral and non-viral infectious diseases of swine, Bovine, companion animals, and <a href=\"https:\/\/poulpharm.com\/\">poultry<\/a>.<br><\/p>\n\n\n\n<div class=\"wp-block-cover\"><img loading=\"lazy\" decoding=\"async\" width=\"982\" height=\"553\" class=\"wp-block-cover__image-background wp-image-2709\" alt=\"\" src=\"https:\/\/connected-pathology.com\/wp-content\/uploads\/2026\/02\/Lawsonia-Fig.1-final.jpg\" data-object-fit=\"cover\" srcset=\"https:\/\/connected-pathology.com\/wp-content\/uploads\/2026\/02\/Lawsonia-Fig.1-final.jpg 982w, https:\/\/connected-pathology.com\/wp-content\/uploads\/2026\/02\/Lawsonia-Fig.1-final-980x552.jpg 980w, https:\/\/connected-pathology.com\/wp-content\/uploads\/2026\/02\/Lawsonia-Fig.1-final-480x270.jpg 480w\" sizes=\"(min-width: 0px) and (max-width: 480px) 480px, (min-width: 481px) and (max-width: 980px) 980px, (min-width: 981px) 982px, 100vw\" \/><span aria-hidden=\"true\" class=\"wp-block-cover__background has-background-dim\"><\/span><div class=\"wp-block-cover__inner-container is-layout-flow wp-block-cover-is-layout-flow\">\n<p class=\"has-text-align-center has-large-font-size\"><\/p>\n<\/div><\/div>\n\n\n\n<p>Fig.1<\/p>\n\n\n\n<p><\/p>\n\n\n\n<div class=\"wp-block-cover is-light\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"561\" class=\"wp-block-cover__image-background wp-image-2710 size-large\" alt=\"\" src=\"https:\/\/connected-pathology.com\/wp-content\/uploads\/2026\/02\/Lawsonia-Fig.2-final-1024x561.jpg\" data-object-fit=\"cover\" srcset=\"https:\/\/connected-pathology.com\/wp-content\/uploads\/2026\/02\/Lawsonia-Fig.2-final-1024x561.jpg 1024w, https:\/\/connected-pathology.com\/wp-content\/uploads\/2026\/02\/Lawsonia-Fig.2-final-980x537.jpg 980w, https:\/\/connected-pathology.com\/wp-content\/uploads\/2026\/02\/Lawsonia-Fig.2-final-480x263.jpg 480w\" sizes=\"(min-width: 0px) and (max-width: 480px) 480px, (min-width: 481px) and (max-width: 980px) 980px, (min-width: 981px) 1024px, 100vw\" \/><span aria-hidden=\"true\" class=\"wp-block-cover__background has-background-dim\" style=\"background-color:#d8a464\"><\/span><div class=\"wp-block-cover__inner-container is-layout-flow wp-block-cover-is-layout-flow\">\n<p class=\"has-text-align-center has-large-font-size\"><\/p>\n<\/div><\/div>\n\n\n\n<p>Fig.2<\/p>\n\n\n\n<p><\/p>\n\n\n\n<p>Figures 1 &amp; 2: Warthin Starry silver stain of swine colon affected with <em>L. intracellularis <\/em>reveal numerous argyrophilic curved small bacilli (arrows) concentrated in the apical cytoplasm of hyperplastic mucosal epithelial cells.<br><\/p>\n\n\n\n<h4 class=\"wp-block-heading\">We invite you to&nbsp;<a href=\"https:\/\/connected-pathology.com\/contact-connected-pathology\/\"><strong>contact us<\/strong><\/a>&nbsp;today to learn how our flexible, state-of-the-art diagnostic services can be tailored to support your specific needs across all species.<br><br><\/h4>\n\n\n\n<p><br><br><\/p>\n","protected":false},"excerpt":{"rendered":"<p>C-path successfully validated Warthin-Starry stain (WS) Which is&nbsp;a silver-based histological special stain used to visualize&nbsp;Lawsonia intracellularis (L. intracellularis) and other microorganisms such as Spirochetes sp., Brachyspira sp., Helicobacter sp. and other argyrophilic (silver-stained) bacteria in histologic sections. WS is of particular importance to visualise L. intracellularis and correlate their presence to the hyperplastic lesions in [&hellip;]<\/p>\n","protected":false},"author":8,"featured_media":2728,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_et_pb_use_builder":"off","_et_pb_old_content":"","_et_gb_content_width":"","_monsterinsights_skip_tracking":false,"footnotes":""},"categories":[3,4],"tags":[],"class_list":["post-2707","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news","category-services"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.5 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>New stain for Lawsonia intracellularis - Connected-Pathology<\/title>\n<meta name=\"description\" content=\"\u00a0A silver-based histological special stain used to visualize\u00a0Lawsonia intracellularis (L. intracellularis)\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/connected-pathology.com\/?p=2707\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"New stain for Lawsonia intracellularis - 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